Synthesis, Characterization and Antimicrobial Activity of Some New Tetrazole Derivatives from Hydrazones

In this investigation, a combination of Z1-Z5 hydrazone compounds is obtained from the reaction between 4-methylbenzohydrazide and aryl-aldehydes. A subsequent unique synthetic approach to the preparation of di-substituted tetrazoles T6-T10 was achieved through a 1,3- dipolar cycloaddition of sodium azide and prepared hydrazone compounds in ethyl alcohol. Results have been verified by Fourier-Transform InfraRed (FT-IR)spectroscopy, 1H and 13C-Nuclear Magnetic Resonance (NMR) spectroscopy, and mass spectrometry. The activity of anti-microbial screening has shown that (Z1–Z6 and T10) presented antifungal activity. The other tested Z2 compound was found to exhibit good antibacterial activity, while the other tested compounds revealed low antibacterial activity.