The Molecular Structure and Case Fatality Rate of COVID-19

A new coronavirus recognized as 2019 novel coronavirus (COVID-19) is the etiological cause in charge of the 2019-2020 viral pneumonia worldwide outbreak. The molecular structure and genome of this virus are identical to SARA-CoV and for an unknown reason, it is highly transmittable. The spike protein is responsible to attach to the host cell and viral single-stranded RNA (ssRNA) entrance to the cells. Upon binding of the Spike proteins to the host cell ACE2 receptor and merging with the membrane, COVID-19 ssRNA goes to the host cells. The viral RNAs are recognized as the foreign element by TLR3, TLR7, TLR8, and TLR9 in the host cell. The viral genome receptor retinoic-acid inducible, cytosolic receptor melanoma differentiation-associated gene and nucleotidyltransferase cyclic GMP-AMP synthase (cGAS) is in charge of viral RNA representation in the cytoplasm.  Now there is no targeted therapeutics with high efficacies for the treatment of Covid 19 disease. More than usual medication some interfering RNA molecules are under debate.  The reason for being high transmission of COVID-19 is not recognized. This virus pandemic is now all over the world.