Comparison of Anti-Inflammatory and Anti-Infection Impact of Cornelian Cherries, Sucralfate, and Intravesical Hyaluronic Acid in a Rat Model of Interstitial Cystitis

Introduction: To assess the effects of treatment with oral Cornu’s mas and sucralfate, and intravesical hyaluronic acid (HA) on bladder histopathology and inflammatory cells in vivo model of Bladder pain syndrome/interstitial cystitis (BPS/IC).  Methods: A total of 25 female rats were grouped: control (group I), IC (group II), HA (group III), Sucralfate (group IV), and Cornu’s mas (group V). Chemical cystitis was induced in four groups (all except the control group) by the intravesical instillation of Hydrogen peroxide, Cornu’s mas extract for 7 days twice a day, sucralfate for seven days twice a day, and HA every week for a month and then every month for two months were administered. Bladder tissue was removed to check inflammatory cell infiltration by histopathological examination.Results: None of the three treatment groups recorded any case of erosion and ulcer, and considering edema, group III recorded one severe case and three mild/moderate cases; and groups IV and V were comprised of mild/moderate cases. Both leukocyte count and mast cell count were significantly higher in group II (P-value=0.033) in comparison to group I. None of the treatments were able to regress the mast cell and leukocyte numbers to the level of the control group (all P-value 0.4).Conclusions: Intravesical injection of HA and oral administration of sucralfate, and Cornu’s mas were able to reduce the inflammation severity but not the normal level in the rat model of BPS/IC.