Synthesis and characterization of some new prodrug polymer based on chitosan with tertiary-butyl acrylate and study some application

Chitosan is a product of the deacetylation of chitin and widely found in the nature. Therefore, the modification of chitosan has been an important aspect of chitosan research. Chitosan have a good solubility, pH-sensitive target also increasing number of delivery systems. The study synthesized rization of some chitosan- amoxicillin H1 and chitosan-diclofenac H2 prodrug and release of drug. The structure of H1 and H2 was analyzed by FT-IR, 1H-NMR, and character TGA. Drug release of prodrug polymers was measured in three different pH (pH=2, 7, and 8) at 37 ℃. From the obtained results, these polymers appear good drug release in a basic medium for an ester bond of polymers as compared with amide bond of the other polymer.