Synthesis, characterization, and in vitro activity of new prepared compunds derivatives from 6-aminqunoline-7-hydroxylic acid

In medical chemistry, aminoqunoline-7-hydroxylic acid is considered as a very useful and attractive nucleus supporting compound. Since then, it has become a central moiety in a variety of bioactive compounds. We synthesised new antioxidants from 6-aminoqunoline-7-hydroxylic acids and determined their antioxidant activity. In cellular and intracellular physiological responses, the peptides are usually considered as the main regulators and widely expected to be used in disease treatment. Due to their therapeutic significance, the two vital molecules, aminoqunolines and peptide derivatives have been combined together into a single molecule by changing the various amino acids synthesized by different chemical reactions. Analysis and valdation of such compunds by Fourier transform infrared (FTIR), 13C and (1H) nuclear magnetic resonance (NMR) spectra was done. The specific optical rotation (SOR) has also been determined. The evaluation of in vitro antioxidant activities of such multifunctional compounds was carried out using the DPPH and Nitric oxide free radical scavenging methods. Activity was noted for derivatives from 6-aminoqunoline-7-hydroxylic acid, while other members showed a higher antioxidant activities than the ascorbic acid. All the five compounds synthesized were studied for their potent antioxdinat activity. A2 and A3 showed highest DPPH scavenging activity at 4 µM. Activity was increased for A3 upto 63.3% and 66.8% on increasing the alkyl chains and polar side chains respctively. A1 was found to exhibit high nitric oxide scavenging activity with 31.2% of activity. This study confirmed the synthesis of new compounds through infrared and NMR spectra. Moreover, they are highly effective in scavenging free radicals.