Synthesis and characterization of some new heterocyclic compounds (hydroqinazoline and thiazinone) prepared from Schiff bases derived from flucytosine drug and study of biological activity

A series of some new heterocyclic six–membered compounds has been synthesized from Flucytosine drug, containing a terminal primary amine group, and was used to prepare a number of new Schiff base compounds bearing the numbers (A1-A4) through interaction with different aldehydes and ketones and using ethanol absolute as a solvent. After that, it was possible to prepare several organic compounds using Schiff bases (A1-A4) prepared in the first step, which contain azomethine group react with (2-aminobenzoic acid and 2-mercaptobenzoic acid) to prepare hydroqinazoline (A5-A8) and thiazinone derivatives (A9-A12). These reactions are followed by TLC and the measurement of melting points for the derivatives. These compounds were determined by FT-IR and by 1H-NMR and 13C-NMR spectra, along with studying the biological activity of the prepared derivatives.