The Effectivity of Honey Bee Towards Mesenchymal Stem Cells Proliferation: A Systematic Review

Context: Using stem cells in the medical field as a regenerative therapy to repair damaged tissue is popular nowadays. Honey contains antioxidant activity, minerals, sugars, and other ingredients supporting wound healing and mature tissue regeneration. However, using honey to induce stem cell proliferation still lacks studies. Objectives: In this review, we would like to do a systematic review to confirm the effectiveness of honey bees towards stem cell proliferation in both in vitro and in vivo treatment. Methods: This study used all previous studies that included honey bees and stem cells in both in vitro and in vivo treatments. The search was performed on July 30th – 31st, 2021, and obtained 21 articles, of which 16 were excluded and the rest were screened. One screened literature was out of the limit; thus, five articles matched the terms. Relevant studies were retrieved from PubMed and the Cochrane Library. Results: According to in vitro studies, honey of Trigonaspp. increases the proliferation rate of dental pulp stem cells (DPSCs). Honey is effective for wound healing and stem cell regeneration. Meanwhile, in vivo studies showed honey increases the regeneration of malnutrition ovary failure. Conclusions: In conclusion, honey positively affects stem cell proliferation and can be used to supplement stem cells.