Hepatoprotective Properties of Cuminum cyminum Seeds Powder as Post-Treatment for Acetaminophen-Induced Injury

Background Objective: Acetaminophen overdose can result in hepatic injury, mainly through oxidative stress. We investigated the protective effect of Cuminum cyminum (C. cyminum) seeds powder after acetaminophen administration. Materials Methods: In this study, 30 male rats were allocated into five groups of six in number as follows: control, acetaminophen (A), and acetaminophen + C. cyminum 200, 400, and 800 mg/kg (A+C). After 24 hours of fasting, the control group received distilled water, and groups A and A+C received acetaminophen 1,000 mg/kg orally through gavage. Six hours later, the control group and group A were given distilled water, and groups A+C received C. cyminum 200, 400, and 800 mg/kg by gavage. Twelve hours after the second gavage, hepatic markers of oxidative stress and serum ALT and AST were assessed. Results: In group A, the activities of serum ALT and AST, the concentration of hepatic malondialdehyde and H2O2 increased, and peroxidase catalase activities decreased substantially compared to the control group. C. cyminum administration in groups A+Cs resulted in the return of these changes toward group control. Conclusion: These results suggest that C. cyminum, due to its flavonoid and polyphenol contents, could diminish hepatic injury induced by acetaminophen.