Title of article :
Acute Lymphoblastic Leukemia Switch Lineage upon Relapse to Acute Bilineage Leukemia: A Case Report
Author/Authors :
mehrzad, valiollah isfahan university of medical sciences - internal medicine department, hematology division, Isfahan, Iran , nematollahi, pardis isfahan university of medical science - omid professional hospital - pathology department, Isfahan, Iran , emami, anahita isfahan university of medical sciences - internal medicine department, hematology division, Isfahan, Iran , hosseini, forough isfahan university of medical sciences - internal medicine department, hematology division, Isfahan, Iran
Abstract :
Although acute leukemia commonly relapses in adults, the conversion of leukemic cell lineage (lymphoid or myeloid) upon relapse has rarely taken place. “Lineage switch” is a term widely used to define the leukemic lineage transformation as assessed by morphology, cytochemistry, and immunophenotyping from diagnosis to relapse. In most lineage switch cases, B-cell lymphoblastic leukemia/ lymphoma relapses as acute myeloid leukemia or vice versa. Here, we report an exceedingly rare case of T-cell acute lymphoblastic leukemia relapsing as mixed phenotype acute leukemia.
Keywords :
Acute lymphoblastic leukemia (ALL) , Lineage switch , Mixed , phenotype acute leukemias , (MPALs) , Acute bilineage leukemia
Journal title :
Iranian Journal of Blood and Cancer (IJBC)
Journal title :
Iranian Journal of Blood and Cancer (IJBC)
