Author/Authors :
Talebian, Narges islamic azad university - Basic Sciences Department, ايران , Talebian, Narges iran university of medical sciences - Cellular and Molecular Research Center, ايران , Parivar, Kazem islamic azad university, ايران , Kafami, Laya Shefa Neuroscience Research Center, ايران , Marzban, Mohsen iran university of medical sciences - Cellular and Molecular Research Center, ايران , Marzban, Mohsen tehran university of medical sciences tums - Anatomy Department, تهران, ايران , Shirmohammadi, Maryam tehran university of medical sciences tums - Anatomy Department, تهران, ايران , Joghataei, Mohammad Taghi iran university of medical sciences - Cellular and Molecular Research Center, ايران , Joghataei, Mohammad Taghi Shefa Neuroscience Research Center, ايران
Abstract :
Introduction: Bone marrow (BM) is a known source of mesenchymal stem cells (MSCs) that are used for cell therapy. This study attempts to identify if the Wharton’s Jelly (WJ) is a suitable substitute for BM as a source for MSCs. Materials and Methods: A population of human WJ and BM stem cells were isolated and incubated with fluorescein conjugated antibodies for five specific MSC markers. Cell populations were subsequently analyzed by flow cytometry. Results: Most of the stem cells isolated from WJ and BM were positive for MSC markers. No significant differences existed between the expression of typical markers of MSCs in WJ isolated cells and that of BM. Conclusion: WJ is a potential replacement for BM as a source of MSCs and can be used for cell therapy in clinical applications.
