Author/Authors :
choi, jin bong the catholic university of kore - bucheon st. mary’s hospital, college of medicine - department of urology, Bucheon, south Korea , cho, kang jun the catholic university of kore - bucheon st. mary’s hospital, college of medicine - department of urology, Bucheon, south Korea , park, won hee inha university college of medicine - department of urology,, Incheon, south Korea , lee, dong hwan lee3 the catholic university of korea - incheon st. mary s hospital, college of medicine - department of urology, Incheon, south Korea , kim, young-ho soonchunhyang university - college of medicine, bucheon hospital - department of urology, Bucheon, south Korea , cho, in rae inje university - ilsanpaik hospital, college of medicine - department of urology, Goyang, south Korea , yoon, hana ewha womans university - school of medicine - department of urology, Seoul, south Korea , kim, young sik national health insurance service, ilsan hospital - department of urology, Goyang, south Korea , kim, joon chul the catholic university of korea - bucheon st. mary’s hospital, college of medicine - department of urology, Bucheon, south Korea
Abstract :
Purpose: We investigated treatment satisfaction with flexible-dose fesoterodine in patients with overactive bladder (OAB) who were dissatisfied with previous anticholinergic therapy. Materials and Methods: The subjects were prescribed fesoterodine 4 mg for 4 weeks and fesoterodine 4 mg or 8 mg for another 8 weeks. The primary end point of this study was patients’ satisfaction after 12 weeks of fesoterodine treatment on a five-point Likert scale. Secondary end points included a change in the number of daytime micturition, urgency incontinence episodes, urgency episodes, and nocturnal micturition in a -24hour period from baseline to final assessment. Results: Overall, 84 patients were assigned to the treatment group in this study and 63 patients completed the -12week treatment course. A final fesoterodine dose of 4 mg and 8 mg was used by %71.4) 45) and %28.6) 18) patients, respectively. The satisfaction and dissatisfaction rates at 12 weeks were %69.9 and %14.2, respectively. Mean changes in the daytime micturitions (4.72 ± 9.73 vs. 2.86 ± 7.76), urgency episodes (5.68 ± 7.73 vs. ± 3.71 4.09), and nocturnal micturitions (1.36 ± 2.13 vs. 1.12 ± 1.68) in 24 hours improved significantly with flexible-dose fesoterodine treatment (P .05). Most adverse events were mild and none were severe.Conclusion: The flexible dose fesoterodine represents an alternative treatment modality in patients with OAB who are dissatisfied with previous anticholinergic therapy in Korea
