Author/Authors :
ataei, neamatollah university of medical sciences - children’s medical center, pediatric chronic kidney disease research center - department of pediatric nephrology, Tehran, Iran , madani, abbas university of medical sciences - children’s medical center, pediatric chronic kidney disease research center - department of pediatric nephrology, Tehran, Iran , esfahani, seyed taher university of medical sciences - children’s medical center, pediatric chronic kidney disease research center - department of pediatric nephrology, Tehran, Iran , otoukesh, hasan iran university of medical sciences - ali-asghar children’s hospital, Tehran, Iran , hooman, nakysa iran university of medical sciences - ali-asghar children’s hospital, Tehran, Iran , hoseini, rozita iran university of medical sciences - ali-asghar children’s hospital, Tehran, Iran , fazel, mojtaba tehran university of medical sciences - imam khomeini hospital complex, Tehran, Iran , derakhshan, ali shiraz university of medical sciences - shiraz nephro-urology research center, Shiraz, Iran , gheissari, alaleh isfahan university of medical sciences - al-zahra hospital, Isfahan, Iran , sorkhi, hadi isfahan university of medical sciences - al-zahra hospital, Isfahan, Iran , abbasi, arash university of medical sciences - children’s medical center, pediatric chronic kidney disease research center - department of pediatric nephrology, Tehran, Iran , fahimi, daryoosh tehran university of medical sciences - bahrami children s hospital, Tehran, Iran , ghane sharbaf, fatemeh mashhad university of medical sciences - sheikh children’s hospital, Mashhad, Iran , mortazavi, fakhrossadat tabriz university of medical sciences - department of pediatrics, Tabriz, Iran , falakaflaki, behnaz zanjan university of medical sciences - mousavi hospital, Zanjan, Iran , nikibakhsh, ahmad ali urmia university of medical sciences, Urmia, Iran , sadeghi bojd, simin zahedan university of medical sciences - department of pediatrics, Zahedan, Iran , hosseini tabatabaei, mohammad taghi zahedan university of medical sciences - department of pediatrics, Zahedan, Iran , ghasemi, kambiz hormozgan university of medical sciences - department of pediatrics nephrology, Bandar Abbas, Iran , ahmadzadeh, ali ahvaz jondishapour university of medical sciences - abozar hospital, Ahvaz, Iran , yousefichaijan, parsa arak university of medical sciences - amirkabir hospital, Arak, Iran , safaei asl, afshin guilan university of medical sciences - department of pediatrics, Guilan, Iran , safaeian, baranak golestan university of medical sciences - taleghani pediatric hospital, Gorgan, Iran , khazaei, salman hamadan university of medical sciences - research center for health sciences, Hamadan, Iran , hejazipour, leila university of medical sciences - pediatric chronic kidney disease research center, children’s medical center - department of pediatric nephrology, Tehran, iran , seyed zadeh, abolhassan kermanshah university of medical sciences - razi hospital, Kermanshah, Iran , ataei, fatemeh university of medical sciences - children’s medical center, pediatric chronic kidney disease research center - department of pediatric nephrology, Tehran, Iran , ataei, fatemeh zanjan university of medical sciences - valiasr hospital - department of nuclear medicine, Zanjan, Iran
Abstract :
Purpose: Knowing the epidemiological aspects of chronic kidney disease (CKD) in children is crucial for early recognition, identification of reversible causes, and prognosis. Here, we report the epidemiological characteristics of childhood CKD in Iran. Materials and Methods: This cross-sectional study was conducted during 1991 - 2009. The data were collected using the information in the Iranian Pediatric Registry of Chronic Kidney Disease (IPRCKD) core dataset. Results: A total of 1247 children were registered. The mean age of the children at registration was 0.69 ± 4.72 years (range, 0.25 –18 years), 7.79 ± 3.18 years for hemodialysis (HD), 4.24 ± 1.86 years for continuous ambulatory peritoneal dialysis (CAPD), and 3.4±1.95 years for the children who underwent the renal transplantation (RT) (P .001). The mean year of follow-up was 7.19 ± 4.65 years. The mean annual incidence of CKD 2–5 stages was 3.34 per million age-related population (pmarp). The mean prevalence of CKD 2–5 stages was 21.95 (pmarp). The cumulative 1-, 5-, and 10-year patients survival rates were 98.3%, 90.7%, and 84.8%, respectively. The etiology of the CKD included the congenital anomalies of the kidney and urinary tract (CAKUT) (40.01%), glomerulopathy (19.00%), unknown cause (18.28%), and cystic/hereditary/congenital disease (11.14%). Conclusion: The incidence and prevalence rate of pediatric CKD in Iran is relatively lower than those reported in Europe and other similar studies. CAKUT was the main cause of the CKD. Appropriate management of CAKUT including early urological intervention is required to preserve the renal function. Herein, the long-term survival rate was higher among the children with CKD than the literature.
