Mesalazine Modified Carbon Paste Electrode for Voltammetric Determination of Amlodipine

In this study, Mesalazine modified carbon paste electrode (MESA-CPE) was developed and utilized to investigate the electrochemical behavior and determination of amlodipine (AML). The electroanalytical responses were evaluated by cyclic voltammetry, chronoamperometry and differential pulse voltammetry. The MESA/CPE showed good electrocatalytic activity with respect to the electrooxidation of AML with an over potential of 200 mV lower than that of the bare CPE. The sensor showed two linear dynamic ranges from 1.0 to 20.0 μM and 20.0 to 100.0 μM with a detection limit of 0.4 μM (S/N = 5). The MESA-CPE was applied for the determination of AML in some pharmaceutical formulations.