Title of article :
Human cardiac organoids: A recent revolution in disease modeling and regenerative medicine
Author/Authors :
Roshanravan ، Neda Cardiovascular Research Center - Tabriz University of Medical Sciences , Ghaffari ، Samad Cardiovascular Research Center - Tabriz University of Medical Sciences , Bastani ، Sepideh Department of Immunology - Leiden University Medical Science , Pahlavan ، Sara Department of Stem Cells and Developmental Biology - Cell Science Research Center - Royan Institute for Stem Cell Biology and Technology , Asghari ، Samira University of Social Welfare and Rehabilitation Sciences , Doustvandi ، Mohammad Amin Immunology Research Center - Tabriz University of Medical Sciences , Jalilzadeh-Razin ، Sepideh Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute - Tabriz University of Medical Sciences , Dastouri ، Mohammadreza SISBIYOTEK Advanced Research Unit - Ankara University Biotechnology Institute
Abstract :
Three-dimensional (3D) myocardial tissues for studying human heart biology, physiology and pharmacology have recently received lots of attention. Organoids as 3D mini-organs are created from multiple cell types (i.e. induced pluripotent stem cells (iPSCs) or embryonic stem cells (ESCs)) with other supporting co-cultured cells such as endothelial cells or fibroblasts. Cardiac organoid culture technologies are bringing about significant advances in organ research and allows for the establishment of tissue regeneration and disease modeling. The present review provides an overview of the recent advances in human cardiac organoid platforms in disease biology and for cardiovascular regenerative medicine.
Keywords :
Organoid , Regenerative Medicine , Three , Dimensional Culture , Pluripotent Stem Cells
Journal title :
Journal of Cardiovascular and Thoracic Research (JCVTR)
Journal title :
Journal of Cardiovascular and Thoracic Research (JCVTR)
