Title of article :
The Frequency of Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer Samples in Algeria
Author/Authors :
Dahmani ، Bouchra Department of Natural Sciences of Life, Earth and Universe - Faculty of Biology - University of Abou Bekr Belkaid , Boublenza ، Lamia Department of Natural Sciences of Life, Earth and Universe - Faculty of Biology - University of Abou Bekr Belkaid , Behar ، Dalale Department of Natural Sciences of Life, Earth and Universe - Faculty of Biology - University of Abou Bekr Belkaid , belatbi ، Belkacem Department of Pathological Anatomy - Popular Hospital Establishment of Dr. Benzardjeb , Breik ، Ikram Department of Pathological Anatomy - Popular Hospital Establishment of Dr. Benzardjeb , Benfoula ، Amel Department of Pathological Anatomy - Popular Hospital Establishment of Dr. Benzardjeb , Chabni ، Nafissa Department of Epidemiology - University of Abou Bekr Belkaid , Hassaine ، Hafida Department of Natural Sciences of Life, Earth and Universe - Faculty of Biology - University of Abou Bekr Belkaid
Abstract :
Background: Environmental factors may play a role in colon cancer. In this view, several studies investigated tumor samples for the presence of various viral DNA with conflicting results. The purpose of this study is to investigate the prevalence of Human papillomaviruses (HPVs) and Epstein-Barr virus (EBV) in patients with colorectal carcinomas. Materials and Methods: In this study, we collected 74 tumorous paraffin-embedded tissues (Mean±SD age: 66.3±14.98) from the Pathology Department of a hospital in Ain Temouchent and laboratories of pathological anatomy in western Algeria. DNA from each tissue was extracted and the presence of HPV and EBV was investigated using PCR. Results: None of our samples were HPV or EBV positive, and we failed to find an obvious correlation between EBV and HPV infections and this type of cancer. Conclusion: The results suggested that EBV and HPV infection is not common in patients with colorectal cancer in our population. However, the findings merit more investigations on a large number of cases.
Keywords :
HPV human papillomavirus , Epstein , Barr virus , Colorectal cancer , Algeria , Polymerase chain reaction , PCR
Journal title :
Research in Molecular Medicine
Journal title :
Research in Molecular Medicine
