The Effect of Selen plus Supplementation during Aerobic Training on Nitric Oxide and Myeloperoxidase in Women with Metabolic Syndrome

Introduction: Obesity and metabolic syndrome are associated with inflammation, vascular endothelial dysfunction and cardiovascular complications. In this study, the aim was to investigate the effect of aerobic training combined with Selen Plus supplementation on the serum levels of nitric oxide and myeloperoxidase in obese women with metabolic syndrome. Methods: In this quasi-experimental study, 48 obese women (30 ≤ BMI ≤ 36) with metabolic syndrome aged 30-45 years were randomly divided into 4 groups: control (no intervention); Selen Plus (1000 grams/daily); aerobic training (every other day) and combined group (aerobic training + selen plus). Fasting levels of nitric oxide and myeloperoxidase and anthropometric indices were measured before and 48 hours after the final training session in each group. ANCOVA statistical test was used to compare the data and paired t-test was used to determine intra-group changes (p 0.05). Results: Compared to the control group, serum nitric oxide significantly increased and myeloperoxidase significantly decreased in the aerobic, selen plus and combined groups (p=0.001). Nitric oxide in the combined group increased significantly compared to selen plus group (p=0.042). Conclusion: Selen plus supplementation during aerobic training is associated with improvement of vascular endothelial function indices in women with metabolic syndrome compared to its use alone.