Author/Authors :
Chung ، Jae-Wook Department of Urology - School of Medicine, Chilgok Hospital, Joint Institute for Regenerative Medicine - Kyungpook National University , Kim ، Jin Woo Department of Urology - School of Medicine, Chilgok Hospital - Kyungpook National University , Lee ، Eun Hye Joint Institute for Regenerative Medicine - Kyungpook National University Hospital , Chun ، So Young BioMedical Research Institute - Kyungpook National University Hospital , Park ، Dong Jin Department of Urology - Dongguk University School of Medicine , Byeon ، Kyeong Hyeon Department of Urology - School of Medicine, Chilgok Hospital - Kyungpook National University , Choi ، Seock Hwan Department of Urology - School of Medicine, Chilgok Hospital - Kyungpook National University , Lee ، Jun Nyung Department of Urology - School of Medicine, Chilgok Hospital - Kyungpook National University , Kim ، Bum Soo Department of Urology - School of Medicine, Chilgok Hospital - Kyungpook National University , Kim ، Hyun Tae Department of Urology - School of Medicine, Chilgok Hospital - Kyungpook National University , Yoo ، Eun Sang Department of Urology - School of Medicine, Chilgok Hospital - Kyungpook National University , Kwon ، Tae Gyun Department of Urology - School of Medicine, Chilgok Hospital, Joint Institute for Regenerative Medicine - Kyungpook National University , Ha ، Yun-Sok Department of Urology - School of Medicine, Chilgok Hospital, Joint Institute for Regenerative Medicine, - Kyungpook National University , Kim ، Tae-Hwan Department of Urology - School of Medicine, Chilgok Hospital - Kyungpook National University
Abstract :
Purpose: In this study, we evaluated the predictability of a modified Club Urológico Español de Tratamiento Oncológico (CUETO) scoring model and preoperative neutrophil-to-lymphocyte ratio (NLR) in patients with non-muscle invasive bladder cancer (NMIBC). Materials and Methods: From August 2005 to May 2016, a total of 281 patients received intravesical bacillus Calmette–Guérin therapy after transurethral resection of a bladder tumor. The pathologic stage of all patients was Ta or T1. Of 281 patients, 84 (29.9%) experienced recurrence and 14 (5.0%) developed progression. The mean follow-up period was 46 months. The cut-off value for NLRs was 2.29. Results: One hundred-eight patients (38.4%) displayed a high NLR ( 2.29). In Kaplan–Meier curve analysis, a high NLR was associated with lower recurrence-free survival (RFS) (P .001) and progression-free survival (PFS) (P = .002). CUETO scores were associated with RFS (P .001), but not with PFS (P = .423). A combination of NLRs and the CUETO risk model correlated with RFS (P .001) and PFS (P = .002). In multivariate analysis, female gender, concomitant carcinoma in situ (CIS), tumor number 3, recurrent tumors, and a high NLR were independent factors predicting recurrence (all P .05). Concomitant CIS, recurrent tumors, and a high NLR were independent factors for predicting progression (all P .05). Conclusion: In patients with NMIBC, an NLR 2.29 was identified as a significant factor for predicting tumor recurrence and progression. Inclusion of preoperative NLR enhanced the accuracy of the CUETO model to predict disease progression.
Keywords :
Neutrophil , to , lymphocyte ratio , Bacillus Calmette–Guérin , Club Urológico Español de Tratamiento Oncológico risk model , Survival
