The Resistance Training Effects on Skeletal Muscle Stem Cells in Older Adult: A Systematic Review and Meta-Analysis

The objective of this systematic review and meta-analysis is to examine the effects of resistance exercise training on muscle stem cells in older adults. A database search was performed (PubMed, Scopus, Web of Science and Google Scholar) to identify controlled clinical trials in English language. The mean difference (MD) with 95% confidence intervals (CIs) and overall effect size were calculated for all comparisons. The PEDro scale was used to assess the methodological quality. Nineteen studies were included in the review. The meta-analysis found a significant effect of resistance training (RT) on muscle stem cells in the elderly (difference in means=-0.008, Z=-3.415, P=0.001). Also, muscle stem cells changes were similar in men and women (difference in means=-0.004, Z=-1.558, P=0.119) and significant changes occur in type II muscle fibers (difference in means=-0.017, Z=-7.048, P=0.000). Resistance-type exercise training significantly increased muscle stem cells content in intervention group that this result is similar in men and womenthis increase occurred more in type II muscle fibers.