New-Onset Systemic Lupus Erythematosus during Pregnancy: A Case Report

Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that involves multiple organs. Pregnant women previously diagnosed with SLE are at risk of experiencing gestational complications. However, cases of initial SLE manifestation during pregnancy are rare.Case Presentation: A 45-year-old pregnant woman (G7P2Ab4) was admitted to Shahid Rahimi Hospital in Khorramabad, Iran, in the 29th week of gestation due to thrombocytopenia. The patient had received a diagnosis of SLE during a routine prenatal visit but had not responded to the prescribed medications. After a comprehensive clinical and paraclinical evaluation, the patient was treated with pulse intravenous methylprednisolone, followed by prednisolone, dramatically improving her clinical condition.Conclusion: Diagnosing and managing SLE during pregnancy can be controversial. An accurate evaluation of the patient’s clinical condition is essential for determining the most effective treatment strategy. A multidisciplinary approach is necessary to ensure the best possible outcomes for the mother and the fetus.