Metal-Organic Frameworks in Systems of Drug Delivery: Review

Drug delivery systems (DDSs) have become a crucial aspect of cancer therapy, and researchers are continuously striving to identify the optimal methods for targeted delivery and release of therapeutic agents. Metal-Organic Frameworks (MOFs) have emerged as a promising class of materials for DDSs due to their exceptional storage capacity, unique characteristics, and high durability. This comprehensive review explores the wide-ranging applications of MOFs in various fields, including catalysis, gas separation and storage, fuel purification, water treatment, medication administration, and imaging. The review paper evaluates different approaches to synthesize MOFs, such as the self assembly of metal ions and clusters and the solvothermal method, to optimize their performance characteristics. The present study aims to shed light on the numerous challenges associated with utilizing MOFs in clinical settings. However, MOF nanocomposites that incorporate reinforcement phases represent a promising strategy for addressing these issues. With the incidence of cancer on the rise, targeted MOFs offer a potential solution to the lack of the selectivity of certain drugs by virtue of their distinctive physical and chemical properties. This investigation delves into how MOFs can be employed to regulate drug release in DDSs and presents research on the key applications of MOFs in the realm of cancer therapy. The application of UiO-66 for drug delivery systems and exploring the different physical characteristics and chemical structures of dicarboxylate ligands incorporated into UiO-66 topology MOFs were investigated. Overall, the review paper provides a comprehensive overview of the diverse applications of MOFs and their potential for drug delivery systems in cancer therapy.