Title of article :
Synthesis of Aureobasidin B Analogs and Their Antifungal Activity Against Candida albicans
Author/Authors :
Maharani ، Rani Department of Chemistry - Faculty of Mathematics and Natural Sciences - Universitas Padjadjaran , Hidayat ، Ika Wiani Department of Chemistry - Faculty of Mathematics and Natural Sciences - Universitas Padjadjaran , Hidayat ، Ace Tatang Department of Chemistry - Faculty of Mathematics and Natural Sciences - Universitas Padjadjaran , Harneti ، Desi Department of Chemistry - Faculty of Mathematics and Natural Sciences - Universitas Padjadjaran , Nurlelasari ، Nurlelasari Department of Chemistry - Faculty of Mathematics and Natural Sciences - Universitas Padjadjaran , Supratman ، Unang Department of Chemistry - Faculty of Mathematics and Natural Sciences - Universitas Padjadjaran
Abstract :
Aureobasidins (Abs) are a class of cyclodepsipeptides with interesting antifungal properties but they are difficult to synthesize. This study aimed to synthesize analogs of aureobasidin B (AbB) by a combination of solid- and solution-phase synthesis and to investigate their antifungal properties. The linear peptides were synthesized on 2-chlorotrityl chloride resin with Fmoc strategy and a range of coupling reagents including HATU/HOAt, HBTU/HOBt, and BTC/sym-collidine. The cyclization step was undertaken in the solution phase. Four cyclic nonapeptides (NP1-NP4) and ten cyclic heptapeptides (HP1-HP2, HP4-HP11) were successfully synthesized and characterized. The analogs NP1, NP4, HP1, and HP2 demonstrated moderate antifungal activity against Candida albicans.
Keywords :
Aureobasidin B , Cycloheptapeptides , Cyclononapeptides , Solid , phase peptide synthesis
Journal title :
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
Journal title :
Iranian Journal of Chemistry and Chemical Engineering (IJCCE)
