Title of article :
The Role of High-Fructose Diet in Liver Function of Rodent Models: A Systematic Review of Molecular Analysis
Author/Authors :
Mirzaei ، Roya Department of Toxicology and Pharmacology - Faculty of Pharmacy and Pharmaceutical Sciences - Islamic Azad University, Tehran Medical Sciences , Khosrokhavar ، Roya Food and Drug Laboratory Research Center - Food and Drug Administration, MOH ME , Arbabi Bidgoli ، Sepideh Department of Toxicology and Pharmacology - Faculty of Pharmacy and Pharmaceutical Sciences - Islamic Azad University, Tehran Medical Sciences
Abstract :
The present systematic review of animal studies on long-term fructose intake in rodents revealed a significant decrease in the activities of antioxidant enzymes due to a fructose-rich diet. The reduced activity of these enzymes led to an increase in oxidative stress, which can cause liver damage in rodents. Of eight studies analyzed, 5 (62.5%) and 1 (12.5%) used male and female rats, respectively, while 2 studies (25%) used female mice. Moreover, half of the studies used high-fructose corn syrup, but the other half employed fructose in the diet. Hence, it is essential to monitor dietary habits to ensure public health and nutrition research outcomes.
Keywords :
Animal model , Fructose , Liver , Liver function tests , Oxidative stress
Journal title :
Iranian Biomedical Journal(IBJ)
Journal title :
Iranian Biomedical Journal(IBJ)
