Promethazine Hydrochloride Influence on the Micellization and the Surface Properties of Sodium Dodecyl Sulfate in Aqueous Solutions Containing Electrolytes at Various Temperatures

The micellization of sodium dodecyl sulphate (SDS) with promethazine hydrochloride (PMZ) in water/electrolyte environment was investigated using the conductivity measuring technique. In aqueous solutions of water, sodium chloride (NaCl), potassium chloride (KCl), and ammonium chloride (NH4Cl) at various concentrations and temperatures, a number of physico-chemical parameters, including the critical micelle concentration (CMC), fraction of bound counter ions (β), and thermodynamic properties (ΔG°m, ΔH°m, ΔS°m, and(ΔC°m), were determined for the SDS/PMZ mixture. The findings demonstrated that the CMC values decreased in the presence of PMZ and continued to decline monolitically in the electrolytic media (NaCl, KCl, and NH4Cl), with the order being CMCNaCl CMCKCl CMCNH4Cl. The SDS/PMZ mixture s CMC values changed with temperature. The negative values of ΔG°m suggested that a spontaneous aggregation event existed in the SDS/PMZ system. The values of ΔH°m and ΔS°m showed that the PMZ molecule interacted with SDS via hydrogen bonds, ion-dipoles, and hydrophobic interactions. In addition, the system s standard molar heat capacity (ΔC°m) was assessed and established with the required reasons. These results might offer a solid scientific basis for the continued use of this model as medication delivery systems.