Title of article :
Investigation of the Relationship between HIWI3 rs11703684 (C T) Polymorphism and Idiopathic Azoospermia/Oligozoospermia in the Kurdish Population of Kermanshah
Author/Authors :
Salimi ، Sara Department of Molecular Genetics - Islamic Azad University, Ahar Branch , Ghorbian ، Saeid Department of Molecular Genetics - Islamic Azad University, Ahar Branch , Alibakhshi ، Reza Department of Biochemistry - School of Medicine - Kermanshah University of Medical Sciences , Keshavarzi ، Farahnaz Department of Obstetrics Gynecology - , Kermanshah University of Medical Sciences
From page :
279
To page :
287
Abstract :
Background Objective: Genetic factors play a major role in the development of male idiopathic infertility. Because of the multi-genetic base of this disease, not all genetic factors have been investigated. PIWI genes have been reported to be involved in the regulation of piRNAs in spermatogenesis. Our study assessed the association between HIWI3 rs11703684 (C T) gene polymorphism with the risk of male idiopathic azoospermia/oligozoospermia in the Kurdish population of Kermanshah. Materials Methods: In this case-control investigation, we included two hundred individuals consisting of 100 men with idiopathic azoospermia/oligozoospermia and 100 fertile men as the control group. To determine genotypes of HIWI3 C T polymorphism, we used the Tetra Arms-PCR technique and significant values were considered as p 0.05. Results: Our findings did not show a statistically significant difference in the genotype frequency of the recessive model (P = 0.118; OR = 0.158; CI, 0.019–1.339), dominant (P = 0.169; OR = 0.625; CI, 0.341–1.144) and co-dominant (P = 0.527; OR = 0.778; CI, 0.417–1.450). In addition, the results described a negative difference in allelic frequency of HIWI3 (rs11703684 C T) in men with idiopathic azoospermia/oligozoospermia and control group (P = 0.288; OR = 0.749; CI, 0.463–1.212). Conclusion: The current study does not indicate the probability effect of HIWI3 rs11703684 (C T) gene polymorphism on the male idiopathic azoospermia/oligozoospermia in the Kurdish population of Kermanshah. The critical role of PIWI genes in spermatogenesis and as a candidate risk factor for male infertility remained unknown.
Keywords :
Azoospermia , Oligozoospermia , rs11703684 , PIWI , HIWI3 gene , Polymorphism
Journal title :
Journal of Advanced Biomedical Sciences (JABS)
Journal title :
Journal of Advanced Biomedical Sciences (JABS)
Record number :
2754584
Link To Document :
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