Title of article :
Frequency, Bacteriological Profile, and Outcome of Neonatal Sepsis with Carbapenem-Resistant Gram-Negative Bacteria at the Tertiary Neonatal Intensive Care Unit, Ahvaz, Iran
Author/Authors :
Aletayeb ، Mohammad Hassan Department of the Pediatrics - Imam Khomeini Hospital - Ahvaz Jundishapur University of Medical Sciences , Dehdashtian ، Masoud Department of the Pediatrics - Imam Khomeini Hospital - Ahvaz Jundishapur University of Medical Sciences , Malakian ، Arash Department of the Pediatrics - Imam Khomeini Hospital - Ahvaz Jundishapur University of Medical Sciences , Aramesh ، Mohammad Reza Department of the Pediatrics - Imam Khomeini Hospital - Ahvaz Jundishapur University of Medical Sciences , Kouti ، Leila Department of Clinical Pharmacy - Faculty of Pharmacy - Ahvaz Jundishapur University of Medical Sciences , Aletayeb ، Fateme Faculty of Pharmacy - Ahvaz Jundishapur University of Medical Sciences
From page :
1
To page :
9
Abstract :
Background: One of the leading causes of neonatal mortality in low- and middle-income countries (LMICs) is neonatal sepsis caused by carbapenem-resistant gram-negative bacteria. Objectives: This study aimed to determine the frequency, bacterial profile, and outcome of carbapenem-resistant Gram-negative neonatal sepsis in southwest Iran. Methods: This 15-month retrospective cross-sectional descriptive study was conducted at a level 3 referral training hospital. The study included all neonates hospitalized from birth who had positive blood cultures for Gram-negative bacteria. Patients were divided into carbapenem-resistant and carbapenem-sensitive groups. Results: During the study, Gram-negative bacteria were isolated from the blood cultures of 113 neonates. Positive Gram-negative bacteria blood cultures and carbapenem-resistant cases were 2.38% and 1.52%, respectively. In these cases, 66 (58.4%) of the infants were males, 100 (88.4%) were preterm, and 74 (65.4%) required mechanical ventilation within the first three days of life. The study found 45 (39.8%) infants with early-onset sepsis. Acinetobacterwas the most common isolated organism, while Enterobacterhad the lowest isolation rate. Carbapenem resistance was discovered in 72 (63.7%) positive blood cultures. Acinetobacterhad the highest prevalence of carbapenem resistance, while Pseudomonashad the lowest. Mortality rates in infants infected with carbapenem resistance bacteria (CRB) were 89.3% compared to 10.7% in those infected with carbapenem-sensitive bacteria (CSB). Conclusions: The frequency of carbapenem-resistant Gram-negative sepsis in our ward was 1.52 percent of all admissions, and Acinetobacterbacteria was the most common cause of this type of neonatal sepsis. Infants infected with CRB had a higher mortality rate than those infected with CSB, 89.3% versus 10.7%.
Keywords :
Neonate , Sepsis , Gram Negative Bacteria , Antibiotics , Carbapenem
Journal title :
Jundishapur Journal of Microbiology (JJM)
Journal title :
Jundishapur Journal of Microbiology (JJM)
Record number :
2754598
Link To Document :
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