Title of article :
Macrolide-resistant Mycoplasma pneumoniae in an Iranian Pediatric Sample with Community-Acquired Pneumonia
Author/Authors :
Fahimzad ، Alireza Pediatric Infectious Research Center - Shahid Beheshti University of Medical Sciences , Karimi ، Abdollah Pediatric Infectious Research Center - Shahid Beheshti University of Medical Sciences , Nadji ، Alireza Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases - Shahid Beheshti University of Medical Sciences , Tavousi ، Najmeh Infectious Diseases and Tropical Medicine Research Center - Isfahan University of Medical Sciences , Abedini ، Masomeh Department of Pediatric - Faculty of Medicine - Kurdistan University of Medical Science , Amini ، Roghayeh Department of Pediatric - Faculty of Medicine - Kurdistan University of Medical Science , Hosseininasab ، Ali Infectious and Tropical Research Center - Kerman University of Medical Sciences , Hosseininasab ، Fatemeh Infectious and Tropical Research Center - Kerman University of Medical Sciences , Ghadiri ، Keyghobad Infectious Diseases Research Center, Health Institute - Kermanshah University of Medical Sciences , Chegene Lorestani Sha Masoomshahi ، Roya Clinical Research Development Center, Imam Reza Hospital - Kermanshah University Of Medical Sciences , Aelami ، Mohammad Hassan Department of Pediatrics - Hand Hygiene and Infection Control Research Center - Imam Reza Hospital , Abdinia ، Babak Departments of Infectious Diseases - Pediatric Health Research Center - Tabriz University of Medical Sciences , Hashemian ، Houman Pediatric Diseases Research Center - Guilan University of Medical Sciences , Rezai ، Mohammad Sadegh Pediatric Infectious Diseases Research Center - Mazandaran University of Medical Sciences , Sanaei Dashti ، Anahita HIV/AIDS Research Center - Shiraz University of Medical Sciences , Pourmoghaddas ، Zahra Pediatric Cardiovascular Research Center, Cardiovascular Research Institute - Isfahan University of Medical Sciences
Abstract :
Background: To the best of our knowledge, the prevalence of macrolide-resistant Mycoplasma pneumoniae(MRM) in Iranian children has not been investigated. Objectives: The present study aimed to evaluate the prevalence of MRM in Iranian children with community-acquired pneumonia (CAP). Methods: A total of 222 children with CAP, aged 3 - 15 years, who were hospitalized in 10 different children s hospitals, were enrolled in this study. Mycoplasmas were detected using the polymerase chain reaction (PCR) assay. The severity of CAP was evaluated according to the Infectious Diseases Society of America (IDSA) guidelines. The level of C-reactive protein (CRP) was also measured by the particle-enhanced turbidimetric immunoassay. Additionally, the chest X-rays of children with CAP were recorded and sent to a radiologist for further evaluation. Results: Twenty-one children (9.4%) diagnosed with CAP also had M. pneumoniaeinfection, 17 (77.27%) of whom were positive for A2063G transition and high-level macrolide resistance. The severity of CAP (P ≥ 0.99), CRP level (0.07), and chest X-ray changes (P = 0.08) were not significantly different between children with MRM pneumonia and those with macrolide-susceptible M. pneumoniae. Conclusions: The prevalence of high-level MRM pneumonia in children is high in Iran, similar to other Asian countries. However, this type oMycoplasmainfection was not associated with the severity of CAP and did not have significant effects on chest X-ray (CXR) changes or the CRP level in the patients.
Keywords :
Macrolide Resistant , Mycoplasma , Pediatrics , Pneumonia
Journal title :
Jundishapur Journal of Microbiology (JJM)
Journal title :
Jundishapur Journal of Microbiology (JJM)
