Title of article
Synthesis of DNA-Carbohydrate Conjugate via Diazocoupling: A New Class of Modified DNA with Enhanced Stability and Lectin-Recognition Ability
Author/Authors
Matsuura، Kazunori نويسنده , , Kobayashi، Kazukiyo نويسنده , , Akasaka، Tsukasa نويسنده , , Hibino، Miki نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
-246
From page
247
To page
0
Abstract
Salmon testes DNA was treated with a diazonium salt connected to N-(beta)-lactoside via a spacer chain to yield a diazo coupling product with a degree of substitution of 0.14. The DNA-lactose conjugate kept a typical B-type conformation similar to native DNA, and showed higher melting temperature and stronger nuclease resistance than native DNA. The conjugate was found to acquire a strong binding affinity to galactose-specific lectin RCA120.
Keywords
Goodness of fit , Model diagnosis , Identifiability , Parametric bootstrap , Restricted latent class models
Journal title
CHEMISTRY LETTERS
Serial Year
1999
Journal title
CHEMISTRY LETTERS
Record number
27548
Link To Document