Title of article :
Application of non‑metal nanoparticles, as a novel approach, for improving the stability of blood products: 2011–2021
Author/Authors :
Zadeh Mehrizi ، Tahereh Blood Transfusion Research Center - High Institute for Research and Education in Transfusion Medicine , Shafiee Ardestani ، Mehdi Department of Radiopharmacy - Faculty of Pharmacy - Tehran University of Medical Sciences
From page :
137
To page :
161
Abstract :
Despite the importance of the proper quality of blood products for safe transfusion, conventional methods for preparation and their preservation, they lack significant stability. Non-metal nanoparticles with particular features may overcome these challenges. This review study for the first time provided a comprehensive vision of the interaction of non-metal nanoparticles with each blood product (red blood cells, platelets and plasma proteins). The findings of this review on the most effective nanoparticle for improving the stability of RBCs indicate that graphene quantum dots and nanodiamonds show compat- ibility with RBCs. For increasing the stability of platelet products, silica nanoparticles exhibited a suppressive impact on platelet aggregation. Pristine graphene also shows compatibility with platelets. For better stability of plasma products, gra- phene oxide was indicated to preserve free human serum albumin from thermal shocks at low ionic strength. For increased stability of Factor VIII, mesoporous silica nanoparticles with large pores exhibit the superb quality of recovered proteins. Furthermore, 3.2 nm quantum dots exhibited anticoagulant effects. As the best promising nanoparticles for immunoglobulin stability, graphene quantum dots showed compatibility with γ-globulins. Overall, this review recommends further research on the mentioned nanoparticles as the most potential candidates for enhancing the stability and storage of blood components.
Keywords :
Blood products , Non , metal nanoparticles , Nanodiamonds , Stability , Mesoporous silica nanoparticles
Journal title :
Progress in Biomaterials
Journal title :
Progress in Biomaterials
Record number :
2754815
Link To Document :
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