Author/Authors :
Golmohammadi ، Zahra Student Research Committee - Mashhad University of Medical Sciences , Boostani ، Reza Department of Neurology - Ghaem Hospital - Mashhad University of Medical Sciences , Saeidi ، Morteza Department of Neurology - Ghaem Hospital - Mashhad University of Medical Sciences , Aryan ، Ehsan Department of Microbiology and Virology - Faculty of Medicine - Mashhad University of Medical Sciences , Gholoobi ، Aida Metabolic Syndrome Research Center - Mashhad University of Medical Sciences , Meshkat ، Mojtaba Department of Community Medicine, Faculty of Medicine - Islamic Azad University , Hooshyar Chechaklou ، Amin Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences , Khoshakhlagh ، Mahdieh Department of Biochemistry - Faculty of Medicine - Mashhad University of Medical Sciences , Abolbashari ، Samaneh Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences , Meshkat ، Zahra Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences
Abstract :
Background: Multiple Sclerosis (MS) is a multifactorial disease that causes neurological disability. Human retroviruses may have a role in the etiology of several acute and chronic neurological disorders. Objectives: We aimed to investigate the presence of HTLV-I/II and HIV antibodies in the sera of MS patients to assess the relationship between these infections and MS. Methods: This case-control study was conducted on serum samples of MS patients and individuals admitted to the same hospital with no symptoms of MS as the control group. Samples were examined for HIV and HTLV-I/II antibodies using ELISA kits. Results: A total of 79 people, including 38 MS patients and 41 healthy individuals, were evaluated. The frequency of HIV antibodies was 0.0% in both the case and control groups. The HTLV-I/II antibodies were detected in 1 patient in the control group and no patients in the MS group, with no statistically significant difference between the two groups (P: 0.999). Conclusions: This study could not establish a relationship between the presence of HTLV-I/II or HIV antibodies and MS.
