Author/Authors :
Meshkat ، Mojtaba Department of Community Medicine, Faculty of Medicine - Islamic Azad University , Behjati ، Yeganeh Student Research Committee - Mashhad University of Medical Sciences , Bakhshi ، Mansooreh Department of Microbiology and Virology - Faculty of Medicine - Mashhad University of Medical Sciences , Meshkat ، Zahra Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences , Yazdan Mehr ، Mina Department of Microbiology and Virology - Faculty of Medicine - Mashhad University of Medical Sciences , Boostani ، Reza Department of Neurology - Ghaem Hospital - Mashhad University of Medical Sciences , Saeidi ، Morteza Department of Neurology - Ghaem Hospital - Mashhad University of Medical Sciences , Khoshakhlagh ، Mahdieh Department of Biochemistry - Faculty of Medicine - Mashhad University of Medical Sciences , Hooshyar Chechaklou ، Amin Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences , Najjari ، Mahya Department of Microbiology and Virology - Faculty of Medicine - Mashhad University of Medical Sciences , Abolbashari ، Samaneh Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences , Gholoobi ، Aida Metabolic Syndrome Research Center - Mashhad University of Medical Sciences
Abstract :
Background: Multiple sclerosis (MS) is an autoimmune inflammatory disorder of the central nervous system of unknown etiology, which is believed to be caused by immune dysregulation triggered by genetic and environmental factors, leading to demyelination and axonal loss. Researchers consider infectious agents, like Helicobacter pylori, as these environmental factors. H. pylorican permanently infect someone’s stomach and cause an acute or chronic inflammatory response, in which inflammatory mediators affect the brain and cause a pathologic disease. Methods: In this cross-sectional study, 38 patients with multiple sclerosis who were referred to the Neurology Clinic of Ghaem Hospital were included, and their serum samples were analyzed for IgM, IgA, and IgG antibodies against H. pyloriby using enzyme-linked immunosorbent assay (ELISA). Results were compared with the samples of 41 sex- and age-matched controls admitted to other wards of Ghaem Hospital had no symptoms of MS. In the end, we analyzed the data with SPSS v.20. Results: In this study, 79 patients, including 38 patients with MS disease in the case group and 41 healthy individuals in the control group, were studied. These two groups had no significant differences in demographic characteristics, including age, gender, and occupation. H. pyloriseropositivity was significantly higher in patients with MS than in controls (68.4% vs 39%) (P = 0.009). In addition, comparing H. pyloriseropositivity in 20 of 30 patients with relapsing-remitting MS versus 6 of 8 patients with progressive MS suggested a significant difference between these two groups (P = 0.030). Also, H. pyloriseropositivity had no significant difference between males and females (39.1% vs 58.9%). Conclusions: The prevalence of H. pyloriseropositivity was significantly higher in patients with MS than in control, besides this seems more frequent in a progressive type of MS than in a relapsing-remitting one, suggesting that H. pylorimight be a causal factor for developing progressing MS and this may have an adverse impact on the prognosis and course of the disease.
Keywords :
Helicobacter pylori , Multiple Sclerosis , Serology , IgG Antibodies
