Potential Utilisation of Secretome from Ascorbic Acid-Supplemented Stem Cells in Combating Skin Aging: Systematic Review of A Novel Idea

The secretome of stem cells consists of a spectrum of bioactive factors secreted by stem cells grown in culture mediacytokines,chemokines, and growth factors in addition to extracellular vesicles (exosomes and microvesicles). Easeof handling and storage of secretomes along with their bioactivity towards processes in skin aging and customizabilitymakes them an appealing prospective therapy for skin aging. This systematic review aims to investigate the potentialusage of ascorbic acid (AA)-supplemented stem cell secretomes (SCS) in managing skin aging. We extracted articlesfrom three databases: PubMed, Scopus, and Cochrane. This review includes in vitro, in vivo, and clinical studiespublished in English that discuss the correlation of AA-supplemented-SCS with skin aging. We identified 1111 articlesfrom database and non-database sources from which nine studies met the inclusion criteria. However, the studyresults were less specific due to the limited amount of available research that specifically assessed the effects of AAsupplementedSCS in skin aging. Although further studies are necessary, the AA modification of SCS is a promisingpotential for improving skin health.