Title of article :
Effects of Caffeic Acid on Multi-walled Carbon Nanotubes -Induced Mitochondrial Toxicity in Rat Kidney
Author/Authors :
Salehcheh ، Maryam Nanotechnology Research Center - Ahvaz Jundishapur University of Medical Sciences , Zeidooni ، Leila Toxicology Research Center, Medical Basic Sciences Research Institute - Ahvaz Jundishapur University of Medical Sciences , Dehghani ، Mohammad Amin Toxicology Research Center, Medical Basic Sciences Research Institute - Ahvaz Jundishapur University of Medical Sciences , Alboghobeish ، Soheila Nanotechnology Research Center - Ahvaz Jundishapur University of Medical Sciences , Shirani ، Maryam Toxicology Research Center, Medical Basic Sciences Research Institute - Ahvaz Jundishapur University of Medical Sciences
From page :
1
To page :
8
Abstract :
Multi-walled carbon nanotubes (MWCNTs) are being utilized in various fields. With regard to their numerous applications, MWCNT-induced toxicity has not been extensively investigated. Thus, the present study sheds light on the protective effect of caffeic acid (CA) on mitochondrial toxicity in the kidney caused by MWCNTs in Wistar rats employing the MTT assay as well as reactive oxygen species (ROS) indices, based on measuring glutathione (GSH), mitochondrial membrane potential (MMP), malondialdehyde (MDA), and catalase (CAT) activity. According to the MTT assay, using MWCNTs could significantly diminish mitochondrial viability based on doses. Furthermore, the study findings suggested that MWCNTs could reduce GSH content and CAT activity and subsequently improve mitochondrial ROS formation and damage the mitochondrial membrane of the kidney. The findings also implied that CA could protect renal mitochondria against toxicity induced by MWCNTs by lowering oxidative stress.
Keywords :
Carbon Nanotubes , Caffeic Acid , Oxidative Stress , Kidney , Mitochondria
Journal title :
Jundishapur Journal of Natural Pharmaceutical Products (JJNPP)
Journal title :
Jundishapur Journal of Natural Pharmaceutical Products (JJNPP)
Record number :
2758837
Link To Document :
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