Title of article
The bFGF Can Improve Angiogenesis in Oral Mucosa and Accelerate Wound Healing
Author/Authors
Zare ، Reza Dental Research Center - Mashhad University of Medical Sciences , Abdolsamadi ، Hamidreza Department of Oral Medicine - Dental Research Center - Hamadan University of Medical Sciences , Soleimani Asl ، Sara Department of Anatomy - School of Medicine, Endometrium and Endometriosis Research Centre - Hamadan University of Medical Sciences , Radi ، Shahrbanoo Department of Oral Medicine - Hamedan University of Medical Sciences , Bahrami ، Hossein , Jamshidi ، Shokoofeh Department of Oral and Maxillofacial Pathology - School of Dentistry, Dental Research Center - Hamadan University of Medical Sciences
From page
547
To page
552
Abstract
Background: The role of the basic fibroblast growth factor (bFGF) has well known in the angiogenesis and ulcer healing. In this study, we aimed to evaluate the effects of bFGF on tissue repair in a rat oral mucosal wound. Methods: Musosal wound induced on the lip mucosa of rats and bFGF was injected along the edge of the mucosal defect immediately after surgery. The tissues were collected on days 3, 7 and 14 after the wound induction. The micro vessel density (MVD) and CD34 expression were done by histochemical studies. Results: The bFGF significantly accelerated granulation tissue formation and MVD was increased three days after ulcer induction but decreased 14 days after surgery. The MVD was significantly higher in the bFGF-treated group. The wound area was decreased in all groups time-dependently and a statistically significant difference (p value?) was observed between the bFGF-treated group and untreated group. The wound area was smaller in the bFGF-treated group compared to the untreated group. Conclusions: Our data demonstrated that bFGF can accelerated and facilitated wound healing.
Keywords
bFGF , Healing , Angiogenesis , Wound , Micro Vessel Density.
Journal title
Reports of Biochemistry and Molecular Biology (RBMB)
Journal title
Reports of Biochemistry and Molecular Biology (RBMB)
Record number
2759121
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