Effect of genetic factors on recurrent aphthous in articles published from 2010-2021: A review

Introduction: The main known factors for causing recurrent oral aphthous are genetics and heredity, hematological defects, and immunological disorders. This study was conducted to review the effect of genetic factors on recurrent oral aphthous. Materials and Methods: This study is a literature review that examines the findings derived from existing research articles investigating the influence of genetic factors on the development of recurrent oral aphthous ulcers. The articles on the same topic were selected from available studies on the web, PubMed ISI, Science, Scopus, and Google Scholar, in 10 years from 2013 to 2022. Articles were chosen and assessed based on specific inclusion and exclusion criteria, employing keywords such as genome, oral, recurrent aphthous, and genetic factor as part of the selection process. Results: 31 studies were selected after screening and based on the inclusion and exclusion criteria. Among them, 1, 2, 3, 2, 5, 5, 6, 3, 3, 1 studies which were done subsequently in the years 2022, 2021, 2020, 2019, 2018, 2017, 2016, 2015, 2014, and 2013, were selected. Among them, 9 studies showed no correlation between genetic factors and RAS incidence, and in the 22 remaining studies, a significant correlation was observed between genetic factors and gene expression in RAS patients compared to healthy people. Conclusion: Genetic factors are effective in the occurrence of recurrent oral aphthous in people.