Association of Insulin-Like Growth Factor-1 Gene Single Nucleotide Polymorphism rs10860860 with Type 2 Diabetes

Aims: One extremely important public health challenge worldwide is diabetes mellitus. Type 2 diabetes mellitus is a rising concern around the globe. Early revealing of Type 2 diabetes mellitus is very significant in that morbidity associated with the condition can be decreased. Studies have proposed that insulin-like growth factor-1 has roles similar to that of insulin. The existing study was implemented to reveal the alliance of single nucleotide polymorphism rs10860860 of the IGF-1 gene with Type 2 diabetes mellitus. Materials Methods: This case-control study was conducted in Merjan Hospital in Babylon Province, Iraq, in 2022. The available random sampling method selected two groups of healthy individuals (n=50 as control) and Type 2 diabetes mellitus patients (n=158 as study). The serum levels of glucose and zinc were determined by spectrophotometric method. The serum IGF-1 level was estimated using the sandwich ELISA technique. The students’ T and Chi-square tests were used to assess data in SPSS 21 software. Findings: The different levels of glucose, zinc, and IGF-1 were significant between the two groups. Genotyping frequencies of the IGF-1 gene deviated from Hardy Weinberg equilibrium in the control group (χ2=9.158; p=0.002) while were consistent in the study group (χ 2=2.482; p=0.115). The AT genotype was associated with lower odds of Type 2 diabetes mellitus than those of the wild genotype AA. Conclusion: The AT genotype of IGF-1 gene SNP rs10860860 negatively associates with Type 2 Diabetes Mellitus.