Immunological Role of IL-17A and Biochemical Factors in Patients with Renal Failure Induced by Systemic Lupus Erythematosus

Aims: The current investigation aimed to study the effect of certain parameters, including IL-17A, creatinine, lymphocytes, and basophils, on patients suffering from systemic lupus erythematosus-induced renal failure. Materials Methods: This clinically controlled study involved 105 patients (35 males, 70 females) confirmed to have systemic lupus erythematosus in Thi-Qar Province, Iraq. Researchers collected 5ml of venous blood from 50 healthy controls to conduct immune tests (to determine the levels of IL-17A by ELISA), biochemical tests (to measure creatinine levels by colorimetric method), and CBC tests (to assess lymphocyte and basophil counts). The data was analyzed using SPSS 23 software using the Chi-square and Welch’s T-tests. Findings: The systemic lupus erythematosus rate was 83%, and females exhibited a higher infection rate (66.7%) than males (33.3%). Significant differences between the sexes were identified. Also, significant increases were seen in the levels of IL-17A and creatinine in patients compared to healthy controls. Furthermore, females aged 13-45 were more affected than males. While levels of IL-17A and creatinine were elevated in some patients, lymphocyte and basophil levels were decreased in others compared to the healthy group. Conclusion: IL-17A, creatinine, lymphocytes, and basophils play a fundamental role in the pathogenesis of systemic lupus erythematosus.