Adjunctive Impact of Mitochondria-Targeting Antibiotics for Cancer Stem Cells of Oral Squamous Cell Carcinoma: Proposal for a Novel Approach in Resistant Cases

Oral squamous cell carcinoma (OSCC) is the most common cancer involving the oral and maxillofacial area [1]. OSCC is reported to exert the worst quality of life among the patients suffering from head and neck cancers [2]. Moreover, the rate of survival in these cases and the prognosis of OSCC are the concerning issues among the oncologists and oral and maxillofacial sur-geons [3]. The current proposed treatment options can be a combination of surgical removal, chemotherapy, and radiotherapy [4-5]. Despite the success of the ment-ioned treatment protocols employed in these cases, man-y patients still suffer from low quality of life and short-time survival rate after the surgeries in resistant and metastatic cases [2, 6-7]. These shortcomings have mo-tivated scientists to look for novel treatment options to alleviate the symptoms and improve the patients’ quali-ty of life, especially in resistant and recurrent cases [7].