Title of article
Carboxylated Graphene Oxide as a Nanocarrier for Drug Delivery of Quercetin as an Effective Anticancer Agent
Author/Authors
yaghoubi ، fatemeh Department of Clinical Biochemistry - Faculty of Medicine, Medical Nanotechnology and Tissue Engineering Research Center, Yazd Reproductive Sciences Institute - Shahid Sadoughi University of Medical Sciences , Hosseini Motlagh ، Najmeh Sadat Dapartment of Biomedical Engineering - Meybod University , moradi ، ali Department of Clinical Biochemistry - School of Medicine - Shahid Sadoughi University of Medical Sciences , Haghiralsadat ، Fateme Department of Advanced Medical Sciences and Technologies, Department of Clinical Biochemistry - School of Paramedicine, School of Medicine - Shahid Sadoughi University of Medical Sciences
From page
324
To page
329
Abstract
Background: Enhancing the therapeutic profile of hydrophobic drugs using the development of biocompatible drug delivery systems is an urgent need. Many types of research have been conducted on graphene derivatives owing to their unique characteristics. Methods: In this survey, quercetin (QUER), a natural medicine, was loaded on carboxylated graphene oxide (GO), and cytotoxicity assay and the uptake of QUER into prostate cancer cells (PC3) were evaluated. Results: The release behavior of QUER was temperature- and pH-sensitive. Although QUER was loaded with high efficiency, the released rate was low (23.25% at pH 5.5 and 42 °C). The toxicity and intensity of fluorescence in the FREE QUER were higher than the loaded form. Conclusion: High-capacity loading and controlled release of GO QUER can be recognized as a proper candidate in treating cancer.
Keywords
Drug delivery systems , Graphene oxide , Nanoparticle , Quercetin
Journal title
Iranian Biomedical Journal(IBJ)
Journal title
Iranian Biomedical Journal(IBJ)
Record number
2761294
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