Title of article
Celiac Disease: A Review from Genetic to Treatment
Author/Authors
Jafari ، Erfaneh Pediatric Infectious Disease Research Center - Tehran University of Medical Sciences , Soleymani ، Niloufar Department of Food Hygiene - Islamic Azad University, Science and Research Branch , Hamidi ، Masoud École Polytechnique de Bruxelles-BioMatter Unit - Université Libre de Bruxelles (ULB) , Rahi ، Azar Department of Pathobiology - School of Public Health - Tehran University of Medical Sciences , Rezaei ، Akram Department of Microbiology - School of Medicine - Tehran University of Medical Sciences , Azizian ، Reza Pediatric Infectious Disease Research Center, Biomedical Innovation and Start-Up Association (Biomino) - Tehran University of Medical Sciences
From page
8
To page
14
Abstract
Celiac disease is a complex disorder influenced by genetic and environmental factors. When people with a genetic predisposition to CD consume gluten, an inflammatory response is triggered in the small intestine, and this reaction can be alleviated by the elimination of gluten from the diet. The clinical manifestations of CD vary greatly from person to person and begin at a young age or in adulthood. Influence of genetic factors on CD development is evident in carriers of the DQ2 and/or DQ8 allele. HLA genotypes are associated with gut colonization by bacteria, particularly in individuals suffering from CD. In addition, beneficial gut microbes are crucial for the production of DPP-4, which plays a key role in immune function, as well as metabolic and intestinal health. Therefore, probiotics have been recommended as a complementary food supplement in CD.
Keywords
Celiac disease , Dipeptidyl peptidase 4 , HLA , DQ antigens , Probiotics
Journal title
Iranian Biomedical Journal(IBJ)
Journal title
Iranian Biomedical Journal(IBJ)
Record number
2761330
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