Title of article
Astragaloside interaction of astragalus plant extract (astragalus) on adrenergic receptor alpha-2 as regulation of sympathetic nervous system activity
Author/Authors
Zainul ، Rahadian Department of Chemistry - Faculty of Mathematics and Natural Sciences - Universitas Negeri Padang , Novaliendry ، Dony Department of Electronics Engineering - Faculty of Engineering - Universitas Negeri Padang , Samala ، Agariadne Department of Electronics Engineering - Faculty of Engineering - Universitas Negeri Padang , Oktavia ، Budhi Department of Chemistry - Faculty of Mathematics and Natural Sciences - Universitas Negeri Padang , Yang ، Cheng-Hong Electronic Department - National Kaohsiung University of Science and Technology , Purnamasari ، Devi Department of Radiology - Faculty Health - Universitas Awal Bros , Maahury ، Mirella Department of Chemistry - Faculty of Mathemetics and Natural Sciences - Pattimura University , Rollando ، Department of Pharmacy Program - Faculty of Health Sciences - Universitas Ma Chung , Verawati ، Rismi Department of Chemistry - Faculty of Mathematics and Natural Sciences - Universitas Negeri Padang , Ghifari ، Muhammad Department of Information Technology - Faculty of Computer Sciences - Universitas Brawijaya , Albari ، Muhammad Department of Information Technology - Faculty of Computer Sciences - Universitas Brawijaya , Ghifari ، Muhammmad Department of Information Technology - Faculty of Computer Sciences - Universitas Brawijaya , Azhari ، Putri Department of Agricultural Technology - Faculty of Agricultural Technology - Universitas Andalas , Mandeli ، Riso Department of Environmental Science, Postgraduate Programme - Universitas Negeri Padang
From page
1137
To page
1148
Abstract
This research aims to study the interaction between astragaloside, astragalus plant extract, and adrenergic receptor alpha-2 as a regulation of sympathetic nervous system activity. The research methods used include the use of Pymol, Pyrex, Protein Plus, and Lipinski Rule software for molecular analysis and protein structure characterization. The results showed that astragaloside had a binding affinity of -6.4. In addition, RMSD was found to be 0, 2.515, and 2.703, which indicated the success of astragaloside in interacting with adrenergic receptor alpha-2. Analysis using Protein Plus showed an interaction between astragaloside and adrenergic receptor alpha-2. Lipinski analysis showed that astragaloside has a mass of 618, 10 hydrogen bond donors, 17 hydrogen bond recipients, a logP of -0.0197, and a molar reactivity of 127.710. These findings provide further understanding of the mechanism of astragaloside’s interaction with adrenergic receptor alpha-2, which could potentially regulate sympathetic nervous system activity. This study contributes to the therapies development based on astragalus plant extracts for effective regulation of sympathetic nervous system function.
Keywords
Astragaloside , Astragalus , Adrenergic receptor alpha , 2 (ADRA2) , sympathetic nervous system , molecular interactions
Journal title
Eurasian Chemical Communications
Journal title
Eurasian Chemical Communications
Record number
2763721
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