Effect of genetic glut4 polymorphism on insulin therapy response in patients with type 1 diabetes

SLC2A4 is a gene that encodes for glucose transporter type 4 (GLUT4). The function of GLUT4 is to facilitate glucose absorption from the bloodstream toward the cells. SLC2A4 gene polymorphisms may cause decreased expression of GLUT4, causing blood glucose levels to be raised. A case-control study with a total of 130 participants, including 100 patients receiving exogenous insulin and 30 healthy control participants. Biochemical tests were performed to determine fasting serum glucose (FSG) and glycosylated hemoglobin (HbA1c). The rs121434581 G A single nucleotide polymorphism was detected using the allele-specific polymerase chain reaction (AS-PCR) technique. The distribution of the rs121434581 G A genotype among patients was as follows: 67% were homozygous wild type (GG), 16% were heterozygous (GA), and 17% were homozygous mutant (AA). The SNP of the SLC2A4 gene that was detected in Iraqi type 1 diabetic patients was noted to not significantly affect the response to exogenous insulin.