Author/Authors :
Amini-Salehi ، Ehsan Gastrointestinal and Liver Diseases Research Center - Guilan University of Medical Sciences , Hassanipour ، Soheil Gastrointestinal and Liver Diseases Research Center - Guilan University of Medical Sciences , Joukar ، Farahnaz Gastrointestinal and Liver Diseases Research Center - Guilan University of Medical Sciences , Daryagasht ، Amir Ali Gastrointestinal and Liver Diseases Research Center - Guilan University of Medical Sciences , Khosousi ، Mohammad-Javad Gastrointestinal and Liver Diseases Research Center - Guilan University of Medical Sciences , Aleali ، Maryam Sadat Gastrointestinal and Liver Diseases Research Center - Guilan University of Medical Sciences , Ansar ، Malek Moien Department of Biochemistry - School of Medicine - Guilan University of Medical Sciences , Heidarzad ، Forough Gastrointestinal and Liver Diseases Research Center - Guilan University of Medical Sciences , Abdzadeh ، Elham Gastrointestinal and Liver Diseases Research Center - Guilan University of Medical Sciences , Vakilpour ، Azin Guilan University of Medical Sciences , Mansour-Ghanaei ، Fariborz Gastrointestinal and Liver Diseases Research Center - Guilan University of Medical Sciences
Abstract :
Context: Non-alcoholic fatty liver disease (NAFLD) is progressing considerably worldwide. Identifying the risk factors of NAFLD is a critical step in preventing its progression. Methods: In November 2022, two independent researchers studied seven databases, including PubMed, ISI/WoS, ProQuest, Scopus, SID, Magiran, and Google Scholar, and reference list of relevant articles, searching studies that assessed NAFLD risk factors in the Iranian adult population. Heterogeneity between studies was assessed by Cochran’s test and its composition using I^2 statistics. A random-effects model was used when heterogeneity was observed; otherwise, a fixed-effects model was applied. Egger’s regression test and Trim-and-Fill analysis were used to assess publication bias. Comprehensive Meta-analysis software (version 3) was used for the analyses of the present study. Results: The results of this study showed significant associations between NAFLD with age (n = 15, odds ratio (OR) = 2.12, 95% CI: 1.79 - 2.51), body mass index (n = 46, OR = 5.00, 95% CI: 3.34 - 7.49), waist circumference (n = 20, OR = 6.37, 95% CI: 3.25 - 12.48), waist-to-hip ratio (n = 17, OR = 4.72, 95% CI: 3.93 - 5.66), total cholesterol (n = 39, OR = 1.80, 95% CI: 1.52 - 2.13), high-density lipoprotein (n = 37, OR = 0.53, 95% CI: 0.44 - 0.65), low-density lipoprotein (n = 31, OR = 1.68, 95% CI: 1.38 - 2.05), triglyceride (n = 31, OR = 3.21, 95% CI: 2.67 - 3.87), alanine aminotransferase (n = 26, OR = 4.06, 95% CI: 2.94 - 5.62), aspartate aminotransferase (n = 27, OR = 2.16, 95% CI: 1.50 - 3.12), hypertension (n = 13, OR = 2.53, 95% CI: 2.32 - 2.77), systolic blood pressure (n = 13, OR = 1.83, 95% CI: 1.53 - 2.18), diastolic blood pressure (n = 14, OR = 1.80, 95% CI: 1.48 - 2.20), fasting blood sugar (n = 31, OR = 2.91, 95% CI: 2.11- 4.01), homeostatic model assessment for insulin resistance (n = 5, OR = 1.92, 95% CI: 1.48 - 2.59), diabetes mellitus (n = 15, OR = 3.04, 95% CI: 2.46 - 3.75), metabolic syndrome (n = 10, OR = 3.56, 95% CI: 2.79 - 4.55), and physical activity (n = 11, OR = 0.32, 95% CI: 0.24 - 0.43) (P 0.05). Conclusions: In conclusion, several factors are significantly associated with NAFLD. However, anthropometric indices had the strongest relationship with NAFLD in the Iranian adult population.
