Meglumine Catalysed Green Synthesis of Ethyl-6-amino-5-cyano-2-methyl-4-phenyl-4H-pyran-3-carboxylate Derivatives

An efficient and simple one-pot synthetic protocol has been developed for the first time to synthesize the series of Ethyl-6-amino-5-cyano-2-methyl-4-phenyl-4H-pyran-3-carboxylates. This was achieved by the cyclocondensation of aromatic aldehydes, malononitrile, and ethylacetoacetate in the presence of the catalytic amount of Maglumine as a readily available, reusable, and biodegradable catalyst. This technique is very promising asit provides mild reaction conditions, an environmentally benign greener approach, easy workup process, high yield, less reaction time, low cost, and recycled up to five catalytic cycles without substantial loss of catalytic activity or product yield.