Title of article
The Role of Ketamine in Calcium Changes in Intracellular Homeostasis and Mitochondrial Dysfunction
Author/Authors
Legiran ، Legiran Department of Biomedicine - Faculty of Medicine - Sriwijaya University , Irfannuddin ، Irfannuddin Department of Physiology - Faculty of Medicine - Sriwijaya University , Ahmad ، Ramli Department of Anesthesiology and Intensive Care - Faculty of Medicine, General Hospital of Wahidin Sudirohusodo - Hasanuddin University , Ibrahim ، Nurhadi Department of Medical Physiology - Faculty of Medicine - Indonesia University , Zainal ، Rizal Department of Biomedicine and Department of Anesthesiology and Intensive Care - Faculty of Medicine - Sriwijaya University
From page
1
To page
8
Abstract
Ketamine was formerly introduced as an anesthesia drug and known as a non-competitive antagonist of the N-methyl-D-aspartate receptor (NMDAR). As knowledge grows, recent studies reveal the antidepressant effect of the drug. Moreover, a few investigations indicate that ketamine might be responsible for multiple calcium-regulated signaling pathways. Ketamine is thought to affect calcium homeostasis through several of its targets, such as N-Methyl-D-Aspartate (NMDA), α-amino-3-hydroxy-5-methylisoxazole-4-propionate acid receptors (AMPA), and voltage-dependent calcium channels (VDCCs).
Keywords
Cellular , Ketamine , N , Methyl , D , Aspartate (NMDA) , Pain
Journal title
Journal of Cellular and Molecular Anesthesia
Journal title
Journal of Cellular and Molecular Anesthesia
Record number
2774233
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