Title of article
Effects of Spirulina platensis Supplementation on COVID-19 Severity in Critically Ill Patients: A Randomized Clinical Trial
Author/Authors
Shadnoush ، Mahdi Department of Clinical Nutrition - Faculty of Nutrition and Food Technology - Shahid Beheshti University of Medical Sciences , Santos ، Heitor O. School of Medicine - Federal University of Uberlandia (UFU) , Hatami ، Monireh Department of Food Sciences and Technology - Faculty of Pharmacy - Islamic Azad University, Tehran Medical Sciences branch , Norouzi ، Mehdi Department of Virology - School of Public Health, Research Center for Clinical Virology - Tehran University of Medical Sciences , Taghavi ، Mohsen Department of Nutrition - Islamic Azad University, Olum Tahghighat branch , Cerqueira ، Henrique Santa Capita School of Medicine - University of São Paulo (USP) , Mojani- Qomi ، Mansoore Sadat Department of Food Sciences and Technology - Nutrition and Food Sciences Research Center, Faculty of Pharmacy - Islamic Azad University, Tehran Medical Sciences branch , Bakhshandeh ، Hooman Rajaie Cardiovascular Medical and Research Center - Iran University of Medical Sciences , Rahmani ، Jamal Cancer Research Center - Shahid Beheshti University of Medical Sciences , Javid ، Zainab Department of Nutrition - Farhikhtegan Hospital, Faculty of Medicine - Islamic Azad University, Tehran Medical Sciences branch , Sanaei Delir Zavaragh ، Davood Department of Infectious Diseases - lslamic Azad University of Medical Sciences, Tehran Medical Sciences Branch , Mikaniki ، Fatemeh Department of Internal Medicine - Farhikhtegan Hospital, Faculty of Medicine - Islamic Azad University, Tehran Medical Sciences branch , Chaharmahali ، Arezoo Department of Internal Medicine - Farhikhtegan Hospital, Faculty of Medicine - Islamic Azad University, Tehran Medical Sciences , Ghanavati ، Matin Department of Clinical Nutrition - Faculty of Nutrition and Food Technology - Shahid Beheshti University of Medical Sciences , Nazari ، Mojgan Department of Midwifery - Zeinab (P.B.U.H) School of Nursing and Midwifery - Guilan University of Medical Sciences
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Abstract
Background: Spirulinais a functional food with antioxidant and anti-inflammatory properties. Its anti-inflammatory, antioxidant, antiviral, and immunomodulatory potential may improve certain clinical conditions in patients with coronavirus disease 2019 (COVID-19) in the intensive care unit (ICU). Objectives: This study aimed to investigate the effects of Spirulinasupplementation on clinical conditions in critically ill patients with COVID-19. Methods: A double-blind clinical trial randomized patients admitted to an ICU to receive either Spirulina platensissupplementation (5g/day, n = 97) or to a control group (n = 95). The severity of COVID-19 was assessed using the Acute Physiology and Chronic Health Evaluation (APACHE), National Early Warning Score (NEWS) 2, and Sequential Organ Failure Assessment Score (SOFA). The study also evaluated the length of stay in the hospital and ICU, respiratory support at discharge, and 28-day mortality. In the survival analysis, 126 participants were evaluated (58 in the control group and 68 in the Spirulinagroup). Results: There was no significant difference between the groups in 28-day mortality (HR = 1.07, 95% CI 0.57 - 1.97) or NEWS2 (P = 0.76). However, the SOFA score significantly decreased in the Spirulinagroup compared to the control group (P = 0.03). The Spirulinagroup had a shorter ICU length of stay (7.43 ± 3.98 days) compared to the control group (10.00 ± 4.69 days, P = 0.007). The hospital length of stay was also shorter in the Spirulinagroup compared to the control group (P = 0.001). Conclusions: Spirulinasupplementation reduced disease severity (as measured by the SOFA score) and shortened hospital and ICU length of stay in critically ill COVID-19 patients, but it did not reduce mortality.
Keywords
Spirulina platensis , COVID , 19 , Mortality , Intensive Care Unit , ICU Length of Stay , Adjunctive Therapy
Journal title
Journal of Cellular and Molecular Anesthesia
Journal title
Journal of Cellular and Molecular Anesthesia
Record number
2774252
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