Assessing the cytotoxic functionality of Co-CeO2 nanoparticles towards colon cancer and mouse embryo fibroblast cells

Nowadays, development and currency of cancer led to the conduction of many attempts for finding novel compounds with the ability to subdue a tumor while causing a lower rate of toxicity. The numerous applications of metal oxide nanoparticles in biology and biomedicine are the result of their distinct physical and chemical features. In this regard, we attempted to introduce an uncomplicated, easy, and green approach to produce of pure and 5% cobalt doped cerium oxide nanoparticles (Co-CeO2 NP) through the exertion of Biebersteinia multifidi leaf extract in the form of a proposed compound for cancer treatment. The finding of performed PXRD, FESEM, EDX, and Raman procedures conFig.d the morphology and size of cobalt doped cerium oxide to be spherical along with a size about 10 nm Additionally, MTT assay was implicated to investigate the toxicity impact of synthesized pure and Co-CeO2 NP against colon cancer (CaCo2), and mouse embryo fibroblast (NIH-3T3) cell lines. Accordingly, the non-toxicity of cerium oxide nanoparticles towards cancer and normal cell lines were proved, whereas the Co-CeO2 NP exhibited cytotoxic effects on CaCo2 cell line while the NIH-3T3 cell line was an exception in comparison to doxorubicin as the control. Considering these facts, the adequate inhibitory impact of synthesized Co-CeO2 NP on colon cancer cell line can be affirmed.