Title of article
Pancreas recovery in diabetic rats after low dose curcumin@ZnO nanoparticles oral treatment
Author/Authors
El-ghannam ، Gamal Department of laser applications in Metrology, photochemistry, and agriculture - National Institute of Laser Enhanced Sciences (NILES) - Cairo University , Sobeh ، Eman I. Biological Applications Department - Egyptian Atomic Energy Authority , Korany ، Reda M. S. Pathology Department - Faculty of Veterinary Medicine - Cairo University , Saleh ، Hisham M. Biological Applications Department - Egyptian Atomic Energy Authority , Elfeky ، Souad A Department of laser applications in Metrology, photochemistry, and agriculture - National Institute of Laser Enhanced Sciences (NILES) - Cairo University
From page
149
To page
160
Abstract
The purpose of this study was to explore the pancreas recovery in diabetic rats after treatment with the synthesized, curcumin@zinc oxide nanocomposite (CUR@ZnO NPs). Type 2 diabetes mellitus (T2DM) rats received low-dose treatments with Cur@ZnO NPs (1 mg/kg) for 4 weeks. The results indicated that CUR@ZnO NPs administration completely recovered T2DM rat’s pancreas. Similarly, CUR@ZnO NPs were exceptional in improving the lipid profile of diabetic rats. The immunohistochemical investigation confirmed these results and revealed a complete recovery of pancreas and insulin production all over the pancreatic islets of the CUR@ZnO NPs group than in all other groups. Moreover, lesion scores in the pancreas and liver of T2DM rats given CUR@ZnO NPs showed a prodigious amelioration than the other groups. The previous results confirmed each other and indicate the success of CUR@ZnO NPs administration at low doses in the restoration of pancreas and insulin production in T2DM rats. The obtained results could help and guide the dose of CUR@ZnO NPs required as a novel drug for T2DM pancreas recovery.
Keywords
Immunohistochemistry , Diabetes , Pancreas , Lesion , CUR@ZnO NPs
Journal title
Nanomedicine Research Journal
Journal title
Nanomedicine Research Journal
Record number
2775014
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