Title of article :
Potential Molecular Mechanisms of Bisphenol A in Obesity Development
Author/Authors :
Amiri-Dashatan ، Nasrin Zanjan Metabolic Diseases Research Center - Zanjan University of Medical Sciences , Taheri ، Zahra School of Medicine - Zanjan University of Medical Sciences , Asadi ، Niosha School of Medicine - Zanjan University of Medical Sciences , Jahangiri ، Farnaz School of Medicine - Zanjan University of Medical Sciences , Mozafari ، Nikoo Skin Research Center - Shahid Beheshti University of Medical Sciences , Ramandi ، Marzieh Proteomics Research Center, Faculty of Paramedical Sciences - Shahid Beheshti University of Medical Sciences , Rezaei ، Mitra Genomic Research Center, Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD) - Shahid Beheshti University of Medical Sciences , Nikzamir ، Abdolrahim Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Disease, Faculty of Medicine - Shahid Beheshti University of Medical Sciences , Jahani Sherafat ، Somayeh Laser Application in Medical Sciences Research Center - Shahid Beheshti University of Medical Sciences , Koushki ، Mehdi Department of Clinical Biochemistry - School of Medicine - Zanjan University of Medical Sciences
Abstract :
Bisphenol A (BPA), an endocrine disruptor, is associated with metabolic disorders. However, several studies have suggested that exposure to BPA can cause obesity. It has recently got more attention from scientists as a risk factor for obesity due to its ability to mimic natural estrogens and bind to their receptors. Nonetheless, the molecular mechanism underpinning the environmental etiology of metabolic disorders has not been not fully clarified. In this regard, BPA exposure directly disrupts endocrine regulation, neuroimmune and signaling pathways, and gut microbes, resulting in obesity. In addition, epidemiological studies have revealed a significant relationship between BPA exposure and the development of obesity, although conflicting results have been reported. Therefore, this review summarized the possible role and molecular mechanisms associated with BPA exposure that may lead to obesity based on in vivo and in vivo studies.
Keywords :
Bisphenol A , Endocrine disruptor chemicals , Obesity , Metabolic syndrome
Journal title :
International Journal of Medical Toxicology and Forensic Medicine
Journal title :
International Journal of Medical Toxicology and Forensic Medicine
