Author/Authors :
Arefnia ، Maryam Nuclear medicine department, Clinical research development unit - School of medicine, Shohada Tajrish Hospital - Shahid Beheshti University of Medical Sciences , Hosseinnezhad Ariani ، Toktam Nuclear Medicine Research Center - Mashhad University of Medical Sciences , Ghodsirad ، Mohammadali Nuclear medicine department, Clinical research development unit - School of medicine, Shohada Tajrish hospita - Shahid Beheshti University of Medical Sciences , Alirezaei ، Toktam Cardiology department , Clinical research development unit - Shohada Tajrish hospital - Shahid Beheshti University of Medical Sciences , Hosseinzadeh ، Elinaz Nuclear medicine department, Clinical research development unit - School of medicine, Shohada Tajrish hospital - Shahid Beheshti University of Medical Sciences , Amoui ، Mahesti Nuclear medicine department - School of medicine, Shohada Tajrish hospital - Shahid Beheshti University of Medical Sciences , Pirayesh ، Elaheh Nuclear medicine department - School of medicine, Shohada Tajrish hospital - Shahid Beheshti University of Medical Sciences , Norouzi ، Ghazaal Nuclear medicine department - School of medicine, Shohada Tajrish hospital - Shahid Beheshti University of Medical Sciences
Abstract :
Background: This study aimed to evaluate the relationship between mean platelet volume (MPV) and myocardial perfusion abnormalities in patients with and without Type 2 diabetes mellitus (DM) using myocardial perfusion scans. Materials and Methods: This cross-sectional study compared 49 patients with Type 2 DM without overt cardiovascular symptoms with 49 healthy controls. Both groups underwent myocardial perfusion scans at rest and under stress conditions. Risk factors were assessed and recorded using a special research-made questionnaire. A complete blood count and MPV results were obtained using the Sysmex - KX-21 system. Data were analyzed using SPSS, with a p-value below 0.05 considered statistically significant. Results: No significant differences were observed between the two groups in terms of Summed Stress Score (SSS), Summed Rest Score (SRS), Summed Difference Score (SDS), Ejection Fraction (EF), and End Systolic Volume (ESV). The only marked variance was a higher average platelet count in the control group. Regression analysis revealed that a one-unit increase in MPV correlated with a 0.46 average increase in SRS in the control group (CI: 0.08-0.83, β: 0.46). Conclusion: MPV may serve as a predictive marker for myocardial perfusion abnormalities, especially in individuals without diabetes. This simple metric could act as an early indicator for coronary artery disease.
Keywords :
Mean platelet volume , Myocardial perfusion scan , Diabetes mellitus , Coronary heart disease
