Novel formulations of Kaempferol and its monosaccharide derivatives for healing cancers and microbial infections

Natural compounds isolated from plant species have a potential pharmacological capability and is now regarded to be an alternative therapeutic agent. Flavonoid metabolites have exhibited significant antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. Kaempferol and its monosaccharide derivatives such as kaempferol-3-glucoside and kaempferol 7-O-glucoside as a well-studied bioactive compound have shown remarkable therapeutic activities. As a major therapeutic limitation, this plant-derived metabolite is soluble in ethanol and slightly soluble in aqueous solvents. This property can hinder the clinical application of kaempferol, as recent studies have tried to discovery effective micro and nano formations. In this way, this mini-review has discussed efficacy of these novel formulations in recent years. This study has shown micro and nanocarriers can improve bioavailability property of kaempferol and its monosaccharide derivative derivatives.